Interleukin-6 drives neutrophil-mediated pulmonary inflammation associated with bacteraemia in murine models of colitis

Inflammatory bowel disease (IBD) is associated with a number of immune-mediated extra-intestinal manifestations. Over half of all IBD patients have some form of respiratory pathology, most commonly neutrophil-mediated diseases such as bronchiectasis and chronic bronchitis. Using murine models of colitis, we aimed to identify the immune mechanisms driving pulmonary manifestations of IBD. We found increased neutrophil numbers in lung tissue associated with the pulmonary vasculature in both trinitrobenzenesulfonic acid – and dextran sulfate sodium–induced models of colitis.

Source: American Journal of Pathology - April 20, 2018 Category: Pathology Authors: Sean W. Mateer, Andrea Mathe, Jessica Bruce, Gang Liu, Steven Maltby, Michael Fricker, Bridie J. Goggins, Hock L. Tay, Ellen Marks, Grace Burns, Richard Y. Kim, Kyra Minahan, Marjorie M. Walker, Robert C. Callister, Paul S. Foster, Jay C. Horvat, Philip M Tags: Regular Article Source Type: research