High Frequency of Ovarian Cyst Development in Vhl2B/+;Snf5+/- Mice

The new paradigm of mutations in chromatin modifying genes as driver events in the development of cancers has proved challenging to resolve the complex influences over disease phenotypes. In particular, impaired activities of members of the SWI/SNF chromatin remodeling complex have appeared in an increasing variety of tumors. Mutations in SNF5, a member of this ubiquitously expressed complex, arise in almost all cases of malignant rhabdoid tumor in the absence of additional genetic alterations. Therefore, we studied how activation of additional oncogenic pathways might shift the phenotype of disease driven by SNF5 loss.

Source: American Journal of Pathology - April 20, 2018 Category: Pathology Authors: Yasumichi Kuwahara, Leslie M. Kennedy, Anthony N. Karnezis, E Lorena Mora-Blanco, Arlin B. Rogers, Christopher D. Fletcher, David G. Huntsman, Charles W.M. Roberts, W.Kimryn Rathmell, Bernard E. Weissman Tags: Short Communication Source Type: research