Integrated transcriptomic and regulatory network analyses identify microRNA-200c as a novel repressor of human pluripotent stem cell-derived cardiomyocyte differentiation and maturation

ConclusionsOur analyses demonstrate that miR-200c represses hESC-CM differentiation and maturation. The integrative computation and experimental approaches described here, when applied more broadly, will enhance our understanding of the interplays between miRNAs and TFs in controlling cardiac development and disease processes.
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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AbstractBreast cancer (BC) is the most common malignancy in women with a significant increasing incidence during the reproductive life. However, based on the newest anti-cancer molecular targeting drugs, successful treatments lead to the disease healing particularly in young patients, thus refreshing their motherhood programs. However, as effect of the BC treatment, a premature depletion of the ovarian follicle reserve occurs in more than one-third of patients resulting in permanent infertility. To prevent the cancer treatment-related infertility (CTRI), several options are today utilized. Besides the ovary suppression by ...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 24 February 2020Source: Stem Cell ResearchAuthor(s): L.D. Shuvalova, A.V. Eremeev, A.N. Bogomazova, E.V. Novosadova, E.A. Zerkalenkova, Yu. V Olshanskaya, E.Y. Fedotova, E.S. Glagoleva, S.N. Illarioshkin, O.S. Lebedeva, M.A. LagarkovaAbstractIPSC line RCPCMi004-A was generated from skin fibroblasts collected from a male patient with early onset Parkinson's disease. The patient carries a heterozygous deletion of the exon 2 of PARK2 gene. The reprogramming of fibroblasts was performed with Sendai viruses containing Oct-4, Sox-2, Klf-4 and c-Myc. Pluripotency was confirmed by immunofluoresce...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Pheochromocytoma (PCC) and paraganglioma (PGL) are rare neuroendocrine tumors associated with high cardiovascular morbidity and variable risk of malignancy. The current therapy of choice is surgical resection. Nevertheless, PCCs/PGLs are associated with a lifelong risk of tumor persistence or recurrence. A high rate of germline or somatic mutations in numerous genes has been found in these tumors. For some, the tumorigenic processes are initiated during embryogenesis. Such tumors carry gene mutations leading to pseudohypoxic phenotypes and show more immature characteristics than other chromaffin cell tumors; they are also ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
12th Sayer Vision Research Lecture Dr. Bharti's laboratory developed and functionally validated in vitro models of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelial cells (RPE). The RPE cells, matured on a biodegradable scaffold, formed a functional monolayer patch. The FDA recently approved a phase I/IIa safety and feasibility clinical trial to test an autologous iPSC-RPE patch in patients with the geographic atrophy form of age-related macular degeneration.Air date: 4/21/2020 11:00:00 AM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
The United States Public Health Service Flag Promotion ceremony for Rear Admiral (RADM) Richard W. Childs, promoted to RADM Upper Half O-8 in January 2020, is being webcast live on 3/27/2020 from Masur Auditorium. Richard Childs, MD serves as the Clinical Director of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH). He was commissioned in the USPHS Commissioned Corps as a Lieutenant in 1995 when joined the NCI as an Oncology Fellow. Following fellowship training, he was appointed a tenure-track investigator in the Hematology Branch of the NHLBI where he continues to conduct r...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Analyst, 2020, Accepted Manuscript DOI: 10.1039/C9AN02366F, PaperPatrycja Sokolowska, Kamil Zukowski, iwona Lasocka, Lidia Szulc-Dabrowska, Elzbieta Jastrzebska Stem cells (SCs) are more and more often applied in tissue engineering and cell therapies, e.g. in regenerative medicine. Standard methods of SC differentiation are time consuming and ineffective. Therefore,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
CONCLUSIONS Our results suggest that the overexpression of BMP-1 can promote the osteogenesis of BMSCs and provides an improved method of cell-based tissue engineering. PMID: 32084123 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
MONDAY, Feb. 24, 2020 -- For patients with multiple myeloma (MM) treated with autologous stem cell transplantation (ASCT), long-term outcomes have improved steadily, according to a study published in the Jan. 28 issue of Blood Advances. Katherine K....
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Conditions:   Acute Leukemia;   Myelodysplastic Syndrome Interventions:   Procedure: Hematopoietic Cell Transplantation;   Radiation: Intensity-Modulated Radiation Therapy;   Radiation: Tomotherapy;   Radiation: Total-Body Irradiation;   Radiation: Volume Modulated Arc Therapy Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Myelofibrosis, Stem Cell Transplantation, Survival Intervention:   Sponsor:   Central Hospital, Nancy, France Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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