Seminal suPAR levels as marker of abacterial male accessory gland inflammation in hypogonadism.

Seminal suPAR levels as marker of abacterial male accessory gland inflammation in hypogonadism. Protein Pept Lett. 2018 Apr 18;: Authors: Milardi D, Grande G, Autilio C, Mancini F, De Marinis L, Marana R, Zuppi C, Urbani A, Pontecorvi A, Baroni S Abstract Recent evidences suggest that hypogonadism is an important risk factor for lower urinary tract symptoms and benign prostatic hyperplasia. Several papers have discussed the role of chronic inflammation in the development of BPH, which may be modulated by the hypogonadal state. Soluble urokinase-type plasminogen activator receptor (suPAR), known protein marker of systemic inflammation, can be assayed in the seminal plasma and represents a reliable and sensitive marker of inflammation for the male accessory gland inflammation (MAGI). The aim of this study has been to investigate if seminal suPAR is elevated in MAGI with hypogonadism and if suPAR represent an useful marker of abacterial inflammation in hypogonadism. We included in the study twenty male patients aged between 25 and 55 year-old with secundary postsurgical hypogonadism. The same patients were also evaluated after a 3-month of testosterone replacement therapy (TRT), to evaluate the effect of androgen replacement therapy on suPAR. Ten fertile men have been enrolled as a control group in the protocol. SuPAR concentrations were assayed on seminal plasma using an enzyme-linked immunosorbent assay (ELISA) kit. Hypogonadic patien...
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Tags: Protein Pept Lett Source Type: research