A Desulfurative Strategy for the Generation of Alkyl Radicals Enabled by Visible-Light Photoredox Catalysis.

A Desulfurative Strategy for the Generation of Alkyl Radicals Enabled by Visible-Light Photoredox Catalysis. Angew Chem Int Ed Engl. 2018 Apr 19;: Authors: Qin Y, Xue F, Wang F, Liu J, Di J, Liao Q, Lu H, Zhu M, He L, He H, Zhang D, Song H, Liu XY Abstract Herein, we present a new desulfurative protocol for generating primary, secondary and tertiary alkyl radicals via visible-light photoredox catalysis. A process that involves the generation of N-centered radicals from sulfinamide intermediates, followed by subsequent fragmentation, is critical to forming the corresponding alkyl radical species. This strategy has been successfully applied to conjugate addition reactions that features mild reaction conditions, broad substrate scope (>60 examples), and good functional-group tolerance. PMID: 29671934 [PubMed - as supplied by publisher]
Source: Angewandte Chemie - Category: Chemistry Authors: Tags: Angew Chem Int Ed Engl Source Type: research
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