Trifluoromethanesulfonic Anhydride as a Low-Cost and Versatile Trifluoromethylation Reagent.

We report herein the unprecedented direct trifluoromethylation of (hetero)arenes using trifluoromethanesulfonic anhydride as a radical trifluoromethylation reagent by merging photoredox catalysis and pyridine activation. Furthermore, the introduction of both of the CF3 and OTf groups of trifluoromethanesulfonic anhydride into internal alkynes to access tetrasubstituted trifluoromethylated alkenes is developed. As trifluoromethanesulfonic anhydride is a low-cost and abundant chemical, this protocol provides a cost-efficient and practical route to trifluoromethylated compounds.
PMID: 29673060 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - April 19, 2018 Category: Chemistry Authors: Qing FL, Ouyang Y, Xu XH Tags: Angew Chem Int Ed Engl Source Type: research