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Psoriatic Arthritis: Biomarkers May Predict Drug Response Psoriatic Arthritis: Biomarkers May Predict Drug Response

A 1-step test of 57 synovial tissue proteins may predict which patients with psoriatic arthritis would benefit from adalimumab or abatacept. Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news

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CONCLUSIONS: Dose reduction strategies would increase ustekinumab efficiency in patients that achieve PASI 75 without psoriatic arthritis, diabetes mellitus, previous BT and concomitant treatment with conventional systemic drugs. PMID: 29676189 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Nearly a third of patients with psoriasis (PsO) develop psoriatic arthritis (PsA) at some point in their life. PsA is a debilitating condition that affects the joints, particularly in the fingers and toes and is known to significantly lower patients ’ quality-of-life. As PsA is characterized by a diverse set of clinical features, referral to a qualified rheumatologist, valid diagnosis, and effective treatment is often delayed. It is now known that a delay in treatment of even 6 months may result in irreparable joint damage.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
The role of diet in psoriasis is paramount to patients, but a critical gap exists in synthesizing primary literature in this area. The aim of this study is to perform a systematic review in order to provide evidence-based dietary recommendations for adults with psoriasis and psoriatic arthritis. We used literature from prior systematic reviews as well as additional primary literature from the MEDLINE database (1960-2017) that evaluated the impact of diet on psoriasis. We included observational and interventional studies of patients with psoriasis or psoriatic arthritis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
The International Dermatology Outcome Measures initiative defined a set of domains to be measured in all psoriasis clinical trials. Psoriatic arthritis (PsA) Symptoms is part of this set. This work seeks to define PsA screening in psoriasis clinical trials and to identify appropriate measures for PsA symptoms. The performance of 4 screening tools and the psychometric properties of 3 PsA symptoms measures (Patient Global (PG)-arthritis, Routine Assessment of Patient Index Data-3 (RAPID3) and Psoriatic Arthritis Impact of Disease (PsAID)) were presented to stakeholders in a pre-Delphi, face-to-face meeting.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
Integrating health record data with patient genetic profiles has vast potential to enhance individualized health care for complex cutaneous diseases such as psoriasis. We recently showed using ∼200 genetic markers, psoriasis patients with the highest/lowest risk of psoriatic arthritis (PsA) or cutaneous-only psoriasis (PsC) can be accurately identified. Here, we evaluated whether health record data can be used to enhance the performance of psoriasis subtype prediction. We performed a me ta-analysis on clinical features available from our Michigan (1,570 PsA/PsC patients) and Toronto (644 PsA/PsC patients) genetic cohor...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research
We present these common and distinct imaging manifestations that may potentially help distinguish between the entities in the diagnostic work-up. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Musculoskeletal Radiology - Category: Radiology Authors: Tags: Review Article Source Type: research
AbstractThe aim was to describe the real-world treatment persistence of subcutaneous TNF inhibitors (TNFi) for patients with inflammatory rheumatic disease newly initiating treatment with biologic disease-modifying antirheumatic drugs (bDMARD). This was a retrospective cohort study that extracted data for new users of TNFi between 1 August 2010 and 31 August 2016 from the Australian Optimising Patient outcome in Australian RheumatoLogy (OPAL) registry. Patients were 1:1 propensity-score matched with golimumab based on their age, sex, year of index, C-reactive protein level, baseline treatment combination and disease. Treat...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractA prominent example of human therapeutic protein-drug interaction (TP-DI) is between methotrexate (MTX) and anti-TNF α mAbs. One plausible mechanism for this TP-DI is through the pharmacodynamic effect of MTX on immunogenicity. However, there is no definitive evidence to substantiate this mechanism, and other competing hypotheses, such as MTX suppressing FcγRI expression thereby affecting mAb PK, have also been proposed. In order to understand this mechanism, a cynomolgus monkey study was conducted using golimumab as a model compound. Golimumab elicited high incidences of immunogenicity in healthy cynom...
Source: The AAPS Journal - Category: Drugs & Pharmacology Source Type: research
The efficacy of corticosteroids in patients with psoriatic arthritis (PsA) and inflammatory back pain has not been studied to date. In this controlled trial, we aimed to investigate the comparative performance...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
Abstract OBJECTIVE: To evaluate the prevalence rates of peripheral joint, enthesis, tendon, and bursa abnormalities by power Doppler (PD) ultrasonic examination in patients with psoriatic arthritis (PsA), psoriatic patients without clinical signs of arthritis (non-PsA psoriasis group), and healthy individuals, to detect subclinical PsA. METHODS: A total of 253 healthy volunteers, 242 non-PsA psoriatic patients, and 86 patients with PsA were assessed by 2-dimensional and power Doppler (PD) ultrasound. Peripheral joint, enthesis, tendon, and bursa abnormalities were observed, characterizing abnormal PD. The aff...
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
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