Newsdesk Infectious disease surveillance update

On March 7, 2018, four cases in human beings of encephalitis associated with Borna disease virus 1 infection were reported in Germany, including three deaths. Of the four patients, three had received organs from the same donor who had no clinical signs of the illness, two of these recipients died from their illness. An additional case of encephalitis caused by Borna disease virus 1 was identified in southern Germany, this patient also died from their illness. No epidemiological link was identified between this case and the organ transplant recipients.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Newsdesk Source Type: research

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We present a case of this rare syndrome after autologous stem cell transplant.
Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Case Review Source Type: research
Complications involving the central nervous system (CNS) occur in 9–14% of patients following allogeneic hematopoietic stem cell transplantation (HSCT), including stroke-like episodes, demyelination, encephalitis, and nonspecific neurological symptoms. Here we report a case of multiple sclerosis (MS) like relapsing remitting encephalomyelitis following allogeneic HSCT, which did not respond to disease modifying therapies (DMTs) and “domino” autologous HSCT. A 53-year-old male was treated with allogeneic HSCT for lymphoid blast transformation of chronic myeloid leukemia. Ten months later he presented with ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Various central nervous system (CNS) complications may occur after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which can result in severe clinical problems. Diagnosis is often difficult, as distinctive clinical symptoms may be absent and different neurological disorders may exhibit similar symptoms. Despite the fact that antibodies responding to brain cell surface antigens have become well recognized in several CNS disorders, cases of autoimmune CNS disorders after allo-HSCT have rarely been reported. Here, we report on a patient who developed encephalitis associated with antibodies ag...
Source: International Journal of Hematology - Category: Hematology Authors: Tags: Int J Hematol Source Type: research
HHV-6 is the collective name of two distinct viral species, HHV-6A and HHV-6B, both members of the subfamily betaherpesvirinae, which also includes cytomegalovirus (CMV) and HHV-7. Seropositivity to HHV-6 is greater than 95% in adults in developed countries1 with nearly 80% acquiring the virus by the age of 2 years.2 Of the two species, HHV-6B makes up the vast majority of symptomatic primary infections in infants 3 and is the causative agent of exanthema subitum, also known as roseola infantum.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Conclusions: The intravenous/intratheca administration of donor CMV-specific CTLs may be a safe and effective treatment for CMV encephalitis, especially for patients who suffered from drug-resistant CMV infection. PMID: 31906810 [PubMed - in process]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
ConclusionsConsanguineous marriages account for a genetic “founder effect.” SCID is a pediatric emergency that dictates immediate precautions and curative treatment with HSCT. Due to lack of newborn screening for SCID within the Palestinian population, most patients in this cohort were diagnosed upon clinical symptoms, which led to a delayed diagnosis, harmful administration of contra-indicated live vaccines, delay in HSCT, and poor outcome.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
ou Kaufer Viruses of the genus Roseolovirus belong to the subfamily Betaherpesvirinae, family Herpesviridae. Roseoloviruses have been studied in humans, mice and pigs, but they are likely also present in other species. This is the first comparative analysis of roseoloviruses in humans and animals. The human roseoloviruses human herpesvirus 6A (HHV-6A), 6B (HHV-6B), and 7 (HHV-7) are relatively well characterized. In contrast, little is known about the murine roseolovirus (MRV), also known as murine thymic virus (MTV) or murine thymic lymphotrophic virus (MTLV), and the porcine roseolovirus (PRV), initially incorrect...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Bone Marrow Transplantation, Published online: 19 November 2019; doi:10.1038/s41409-019-0752-5Clinical practice recommendations for the diagnosis and management of human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation: the Japan Society for Hematopoietic Cell Transplantation
Source: Bone Marrow Transplantation - Category: Hematology Authors: Source Type: research
Volume 36, Issue 8, November 2019, Page 520-522 .
Source: Pediatric Hematology and Oncology - Category: Pediatrics Authors: Source Type: research
Purpose of review The current review article focuses on recent advances in the approach to the diagnosis and treatment of human herpesvirus 6B (HHV-6B) in hematopoietic cell and solid organ transplant recipients. Recent findings Over the past few years, key studies have broadened our understanding of best practices for the prevention and treatment of HHV-6B encephalitis after transplantation. Moreover, important data have been reported that support a potential role of HHV-6B reactivation in the development of acute graft-versus-host disease and lower respiratory tract disease in transplant recipients. Finally, increas...
Source: Current Opinion in Infectious Diseases - Category: Infectious Diseases Tags: ANTIMICROBIAL AGENTS: VIRAL: Edited by Roy F. Chemaly Source Type: research
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