Correspondence Colistin versus colistin plus meropenem for severe infections

In their randomised controlled superiority trial, Mical Paul and colleagues1 found that the addition of meropenem to colistin did not improve clinical failure in patients with severe Acinetobacter baumannii infections. The study brings important high-level evidence to the discussion on the use of combination therapies against multidrug-resistant Gram negatives.2
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research

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Multidrug resistant Acinetobacter baumannii is a serious healthcare threat. In fact, the Center for Disease Control recently reported that carbapenem-resistant A. baumannii is responsible for more than 8,500 infections, 700 deaths, and $281 million in healthcare costs annually in the United States with few, if any, treatment options available, leading to its designation as a pathogen of urgent concern and a priority for novel antimicrobial development. It is hypothesized that biofilms are, at least in part, responsible for the high prevalence of A. baumannii nosocomial and recurrent infections because they frequently conta...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Abstract Acinetobacter baumannii is a multidrug-resistant opportunistic pathogen that affects patients with a compromised immune system and is becoming increasingly important as a hospital-derived infection. This pathogen is difficult to treat owing to its intrinsic multidrug resistance and ability to form antimicrobial-tolerant biofilms. In the present study, we aimed to assess the potential use of zerumbone as a novel anti-biofilm and/or anti-virulence agent against A. baumannii. The results showed that zerumbone at sub-inhibitory doses decreased biofilm formation and disrupted established A. baumannii biofilms....
Source: Microbiology - Category: Microbiology Authors: Tags: Microbiology Source Type: research
The objective of this study was to identify and isolate lactic acid bacterial (LAB) strains from the intestinal tracts of pigs and feces of dogs and then characterize them as potential probiotics with antimicrobial activity against multidrug-resistant pathogenic bacteria. In a preliminary isolation screening, 45 of 1167 isolated LAB strains were found to have anti-S. aureus ATCC 27,735 activity. Using 16S rDNA and 16S-23S rDNA intergenic spacer region (ISR) sequences, five of these isolates were further identified as Lactobacillus animalis 30a-2, Lactobacillus reuteri 4-12E, Weissella cibaria C34, Lactococcus lactis 5-12H,...
Source: Archives of Microbiology - Category: Microbiology Authors: Tags: Arch Microbiol Source Type: research
Publication date: June 2020Source: Journal of Global Antimicrobial Resistance, Volume 21Author(s): Jason Farlow, Maia Nozadze, Nino Mitaishvili, Adam Kotorashvili, Nato Kotoria, Keto Arobelidze, Viktoria Tavadze, Tsiuri Simsive, Paata Imnadze, Nabil Latif, Mikeljon P. Nikolich, Michael Washington, Mary K. Hinkle, Paul Kwon, Nino Trapaidze
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Abstract The rise in multidrug resistant (MDR) organisms portends a serious global threat to the healthcare system with nearly untreatable infectious diseases, including pneumonia and its often fatal sequelae, acute respiratory distress syndrome (ARDS) and sepsis. Gram-negative bacteria (GNB) including Acinetobacter baumannii, Pseudomonas aeruginosa, and carbapenemase-producing Klebsiella pneumoniae (CPKP), are among the World Health Organization and National Institutes of Health's high priority MDR pathogens for targeted development of new therapies. Here we show that stabilizing the host's vasculature by genetic...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
ConclusionsThe polymyxin B IV  + IVT pathway is an ideal treatment strategy for XDRA. baumannii. The tigecycline IVT pathway is also a safe treatment option.
Source: Military Medical Research - Category: International Medicine & Public Health Source Type: research
Authors: Rosana Y, Ocviyanti D, Halim M, Harlinda FY, Amran R, Akbar W, Billy M, Akhmad SRP Abstract Pregnant women are usually at risk of urinary tract infections (UTIs) such as asymptomatic bacteriuria. In the current multidrug-resistance era, appropriate diagnosis and treatment should be provided to avoid complications in pregnant women in developing countries, which have limited facilities, such as Indonesia. The aim of this study was to evaluate in vitro susceptibility tests. Urinary isolates were collected from 715 pregnant women who visited eight Community Health Centers in Jakarta, Indonesia, between 2015 a...
Source: Infectious Diseases in Obstetrics and Gynecology - Category: OBGYN Tags: Infect Dis Obstet Gynecol Source Type: research
Publication date: Available online 1 May 2020Source: Veterinary MicrobiologyAuthor(s): Grazieli Maboni, Mauricio Seguel, Ana Lorton, Susan Sanchez
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
ConclusionblaNDM–1-containing bacteria exhibit multidrug resistance, which rapidly spreads and is transferred through efficient plasmid conjugation; the multidrug resistance of these bacteria may be determined by analyzing their drug-resistant plasmids. The presence of ble and tnpA genes suggests a possible hypothesis that blaNDM–1 originates from A. baumannii, which is retained in K. pneumoniae over a long period by transposition of mobile elements.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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