Correspondence It's too soon to pull the plug on antibiotic cycling

Pleun Joppe van Duijn and colleagues1 investigated the relative merits of antibiotic mixing and antibiotic cycling using a cluster-randomised crossover study in eight intensive care units (ICUs); their findings suggested that 9-month periods of cycling and mixing did not change the unit-wide prevalence of antibiotic-resistant, Gram-negative bacteria. We commend the design of this study, both for its scale and grounding in evolutionary theory that was drawn from the work of both experimentalists and mathematical modellers.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research

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AbstractPurpose of ReviewWe conducted a review of the literature describing the most up-to-date diagnosis and treatment options of chronic bacterial prostatitis.Recent FindingsRecurrence after oral antimicrobial therapy is common, due in part to the rising rates of antimicrobial resistance and inability to completely clear the offending bacteria from the prostate following prostatitis. Recent literature has described various treatment options for chronic bacterial prostatitis refractory to conventional antimicrobial agents, including the use of alternative agents such as fosfomycin, direct antimicrobial injections into the...
Source: Current Urology Reports - Category: Urology & Nephrology Source Type: research
Aw Antibiotic resistant bacteria (ARB) have become contaminants of concern in environmental systems. Studies investigating environmental ARB have primarily focused on environments that are greatly impacted by anthropogenic activity. Background concentrations of ARB in natural environments is not well understood. This review summarizes the current literature on the monitoring of ARB and antibiotic resistance genes (ARGs) in environments less impacted by human activity. Both ARB and ARGs have been detected on the Antarctic continent, on isolated glaciers, and in remote alpine environments. The methods for detecting a...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
This study aimed to survey the antibiotic-resistant pattern of H. pylori infection in different geographical locations in this country.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
This study will pave the way for the development of novel antibacterial lead compounds based on a simplified serine template. PMID: 32476294 [PubMed - as supplied by publisher]
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research
In conclusion, the pathogenicity of P. aeruginosa may increase the prevalence of antibiotic-resistant strains. PMID: 32474845 [PubMed - as supplied by publisher]
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
Condition:   Glioma Intervention:   Device: PET/CT, H-MRS and MRI Sponsor:   Tao Xin Not yet recruiting
Source: - Category: Research Source Type: clinical trials
CONCLUSIONS: Modern cementless implants (trabecular metal and cancellous titanium) showed a lower risk of implant contamination and late clinical haematogenous infection. PMID: 32460572 [PubMed - as supplied by publisher]
Source: Hip International - Category: Orthopaedics Authors: Tags: Hip Int Source Type: research
In this study, the secondary metabolites of a lichen-derived actinomycete strain Amycolatopsis sp. YIM 130687 were investigated intensively by using three different media (4#, 302#, and 312#) for fermentation. A total of 21 compounds were isolated from the fermented extraction of the strain. The structures of all compounds were identified by the examination of HRESIMS and NMR spectra. Compounds 1-3, 5, 6, 21 were only found in the cultivation on 302# medium, while compounds 4, 9-11 were only obtained when the strain was cultured on 312# medium. On the other hand, compounds 7, 8, and 20 were only isolated from the fermentat...
Source: Current Microbiology - Category: Microbiology Authors: Tags: Curr Microbiol Source Type: research
Publication date: Available online 25 May 2020Source: Journal of Hazardous MaterialsAuthor(s): Onur Bulut, Huseyin Avni Oktem, M. Deniz Yilmaz
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
This study presents a promising strategy with further testing in vivo, to develop novel antimicrobial agents and strategies to confront emerging antimicrobial resistance.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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