[Correspondence] It's too soon to pull the plug on antibiotic cycling

Pleun Joppe van Duijn and colleagues1 investigated the relative merits of antibiotic mixing and antibiotic cycling using a cluster-randomised crossover study in eight intensive care units (ICUs); their findings suggested that 9-month periods of cycling and mixing did not change the unit-wide prevalence of antibiotic-resistant, Gram-negative bacteria. We commend the design of this study, both for its scale and grounding in evolutionary theory that was drawn from the work of both experimentalists and mathematical modellers.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research