Fratricide of NK Cells in Daratumumab Therapy for Multiple Myeloma Overcome by Ex Vivo Expanded Autologous NK Cells.

CONCLUSIONS: We unravel a fratricide mechanism for daratumumab-mediated NK cell depletion and provide a potential therapeutic strategy to overcome this side effect in daratumumab-treated MM patients.
PMID: 29666301 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - April 17, 2018 Category: Cancer & Oncology Authors: Wang Y, Zhang Y, Hughes T, Zhang J, Caligiuri MA, Benson DM, Yu J Tags: Clin Cancer Res Source Type: research