Metabolic Plasticity Enables Circadian Adaptation to Acute Hypoxia in Zebrafish Cells

Conclusion: We therefor propose that the realignment of metabolic redox oscillations might initiate the observed hypoxia induced attenuation of the transcriptional clock, based on the reduced binding affinity of the CLOCK/BMAL complex to the DNA in an oxidized environment.Cell Physiol Biochem 2018;46:1159 –1174
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research