Effects of early and late adverse experiences on morphological characteristics of Sprague-Dawley rat liver subjected to stress during adulthood.

Effects of early and late adverse experiences on morphological characteristics of Sprague-Dawley rat liver subjected to stress during adulthood. Int J Clin Exp Pathol. 2014;7(8):4627-35 Authors: Vásquez B, Sandoval C, Smith RL, Del Sol M Abstract The literature indicates that early rupture of the maternal bond and social isolation are variables involved in social and emotional behaviors and in increase in anxiety, particularly in stressful situations. The liver plays a role in the adaptation to stress, yet the possible morphologic changes that its structure can suffer have been studied very little. Therefore, the aim here was to ascertain, through the model of altering the early mother-infant bond and the late social bond through isolation, the effect on the stereologic characteristics of the liver in adult Sprague-Dawley rats subjected to intermittent chronic stress. Twenty-five newborn female rats were used, distributed into 5 groups, under standardized lactation and feeding conditions. The experimental groups were exposed to early (E1), late (E2), and early-late (E3) adverse experiences and then subjected to intermittent chronic stress in adulthood. The liver of each animal was isolated, and the stereologic characteristics of Nv, Vv, and Sv of the hepatocytes were determined. The results from the experimental groups were significantly higher than those obtained in the control groups. The highest values were found in group E3 (Nv ...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research