004 T cell specific microRNA-155 regulates the immune landscape of B16f10 melanoma

MicroRNA-155 (miR-155) has recently been shown to regulate anti-tumor immune responses. However, its specific functions within distinct immune cell types during this process have not been delineated utilizing conditional knockout mouse models. In recently published work, we discovered a role for miR-155 expression within the T cell compartment during the immune response to syngeneic B16f10 mouse melanoma tumors. We found that miR-155 expression within T cells is required to limit syngeneic tumor growth and promote interferon gamma (IFN γ) production within the tumor microenvironment.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research