009 Proportion of CD4+ CD49b+ LAG-3+ type 1 regulatory T cells in the blood of psoriasis patients inversely correlates with psoriasis area and severity index

Type 1 regulatory T (Tr1) cells, are Foxp3- IL-10-secreting regulatory T cells implicated as key regulators of peripheral immune tolerance. Recently it was identified that surface expression of CD49b and LAG-3 is sufficient to identify this specific cell lineage. As IL-10 and LAG-3 expression in psoriasis lesions are extremely low, we hypothesized that impaired immune tolerance in psoriasis could be associated with reduced Tr1 cells. To test the hypothesis, we analyzed 12 psoriasis patients' blood& skin tissues, and 8 control blood samples to compare Tr1(CD3+ CD4+ CD8- CD49b+ LAG-3+) cells, Tregs(CD3+ CD4+ CD8- CD25+ CD127-), and activated T(CD3+ CD4+ CD8- CD69+) cells.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
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