019 KLK6-PAR1 signaling drives psoriasiform manifestations in skin and bone

Kallikrein-related peptidase 6 (KLK6) is a serine protease hypothesized to promote inflammation via cleavage of protease-activated receptors PAR1 and PAR2. KLK6 and PAR1/2 are expressed in skin, however their biological roles remain unclear. RNAseq of lesional skin from psoriasis (Ps) patients identified KLK6 as the most-increased KLK family member (n=6; 13-fold; P

Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: Y. Fritz, J. Ludwig, R. Rozic, W. Swindell, R. Midura, J. Gudjonsson, N. Ward Tags: Adaptive and Auto-Immunity Source Type: research