043 Blockade of OX40 signal ameliorates the mortality and activity of systemic lupus erythematosus

OX40 is a costimulatory molecules predominantly expressed on T cells. Its ligand, OX40 ligand (OX40L), is predominantly expressed on antigen presenting cells. Some reports suggested the involvement of OX40L-OX40 axis in the development and exacerbation of lupus. However, it is still unknown if a blockade of OX40 signal can be a therapeutic option of lupus. To examine the effects of OX40 signal blockade in lupus, we used topical imiquimid (IMQ)-induced lupus model in WT and OX40L KO mice. We also used control IgG and anti-OX40L blocking mAb.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
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