062 Involvement of β-catenin/CBP-dependent signaling in the emergence of hapten-induced atopic dermatitis-like dermatitis

Pathological findings of atopic dermatitis (AD) include skin barrier abnormality, allergic inflammation, and dermal fibrotic remodeling. The canonicalWnt/ β-catenin signaling pathway is a fundamental mechanism involved in various biological activities. ICG-001 selectively blocks the interaction of β-catenin with its transcriptional co-activator cyclic-AMP-response-element-binding protein (CBP). Recent studies have provided convincing evidence of the inhibitory effects of ICG-001 on Wnt-driven disease models, including cancer, organ fibrosis, acute lymphoblastic leukemia, and asthma.

Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: H.H. Matsuda, M. Goto, A. Kato, H. Kouji, T. Sakai, Y. Hatano Tags: Adaptive and Auto-Immunity Source Type: research