088 Imbalance of peripheral T follicular helper lymphocyte subsets in active vitiligo

Vitiligo is a chronic auto-immune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system. Interestingly, several studies observed increased anti-melanocyte antibodies in the sera of patients with vitiligo, suggesting the involvement of humoral immunity in disease pathogenesis. Follicular Helper CD4+ T (TFH) cells are specialized providers of B cell help for the production of antibodies and have been shown to play a central role in the pathogenesis of auto-immune diseases, such as systemic lupus disease.

Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: C. Jacquemin, A. Taieb, K. Boniface, J. Seneschal Tags: Adaptive and Auto-Immunity Source Type: research