123 The role of circadian clocks in a murine model of antibody-induced skin inflammation

A central pacemaker coordinates a network of endogenous circadian clocks. The skin itself features a self-sustained, intrinsic clock which may affect our first-line defense against intruders over the course of the day. Epidermolysis bullosa acquisita (EBA) is a subepidermal blistering disease caused by autoantibodies to type-VII collagen. Treatment options are not yet considered satisfactory. Against this background, we aimed at investigating the role of circadian clocks in EBA. We hypothesized that the migration of neutrophils into the skin, which controls the severity of autoantibody-induced tissue damage, is gated by peripheral circadian clocks.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research