124 MicroRNA-3926 promotes apoptosis of SLE CD4+ T cells through inhibiting autophagy by targeting ATG5

Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by impaired T lymphocyte homeostasis, resulting in increased apoptosis and T cell hyperactivation. A wealth of studies has implicated autophagy in the pathogenesis of SLE. However, the mechanisms underlying the regulation of autophagy and apoptosis in SLE remain unclear. The aim of this study was to explore the role of miR-3926 in crosstalk of autophagy and apoptosis in SLE. By qRT-PCR and western blot, we found that the expression of miR-3926 was significantly up-regulated in SLE CD4+ T cells compared with in healthy donors and was inversely correlated with the expression of ATG5, whereas ATG5 mRNA and protein expression was down-regulated.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research