186 Stearoyl-CoA desaturase-5 is upregulated in basal cell carcinoma: A role in aberrant cell proliferation in human skin

Stearoyl-CoA desaturase (SCD), a Δ9-desaturase that converts saturated fatty acids into monounsaturated fatty acids, is an important regulator of lipogenesis, cell proliferation and differentiation. To date, four mouse (14) and two human (1 and 5) isoforms of SCD have been identified. Human SCD-1 is abundantly expressed in lipogen ic tissues, while increased expression of SCD-5 has been reported in the brain and pancreas. Importantly, both isoforms convert stearate to its unsaturated counterpart oleate.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research