222 DNA methylomic profiles of TWIST1, PLS3 and GATA6 genes in Sezary Syndrome

Sezary syndrome (SS) is an aggressive, leukemic variant of cutaneous T cell lymphoma. Clinical and histopathological findings, including T cell receptor gene clonality may not differentiate SS from inflammatory dermatoses. DNA methylation may provide useful biomarkers, which are needed for more reliable diagnosis, therapies, and to provide tools for research into disease mechanisms. Our group has previously reported a positive association in SS between high expression of TWIST1, PLS3 and GATA6 mRNAs with promoter DNA hypo-methylation, as determined by targeted pyrosequencing.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research