299 A genome-wide association study identifies a novel susceptibility locus for total IgE in a Japanese population from Tohoku Medical Megabank cohort study

Immunoglobulin E (IgE) plays a crucial role in immune functions produced mainly by plasma cells. IgE is related to Th2 cell-mediated allergic inflammatory diseases such as atopic dermatitis, asthma, and allergic rhinitis. Studies of twin and family samples ascertained through atopic disease have confirmed that genetic factors are important for affect total serum IgE levels, and account for from 45% to 78% heritability of total IgE levels are observed its levels from studies of twin and family of atopic diseases.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research