482 Itch and pain mediators in non-melanoma skin cancer

Itch and pain have previously been shown to be associated with non-melanoma skin cancers with itch linked with more superficial basal cell carcinoma (BCC) lesions and pain associated with histologic features that involve the deeper dermal processes in squamous cell carcinoma (SCC) lesions. The mediators underlying itch and pain of non-melanoma skin cancers are poorly understood. Biopsies of skin cancer lesions (n=50) underwent immunohistochemistry for PAR2, tryptase, substance P and b-tubulin for nerve fibers.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research