497 Primary cutaneous aspergillosis (PCA) at the site of a skin abrasion covered with cyanoacrylate skin protectant in a neonate

Infection of the skin by Aspergillus speciesmost commonly occurs through direct innoculation of damaged skin, in which case it is called primary cutaneous aspergillosis (PCA). PCA is often a devastating and life-threatening infection that has been described in all age groups. Premature neonates are at particular risk due to a smaller pool of monocytes and neutrophils, impaired T-cell activation and an immature skin barrier as well as considerably decreased cord blood TNF- α and IL-6. Skin maceration, moisture buildup and disruption of barrier integrity are believed to contribute to the pathophysiology of PCA, and occlusive wound dressings, orthotics, latex finger stalls and tape at catheter insertion sites have all been described in conjunction with PCA in the neona tal age group.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research