653 Improving epidermal function normalizes circulating levels of key pro-inflammatory cytokines in aged humans

Elevated circulating levels of three pro-inflammatory cytokines (IL-1 β IL-6 and TNFα) are linked to the development of multiple, age-associated chronic disorders in aged humans (arthrosclerosis, diabetes, and Alzheimers disease. While regimens that reduce levels of circulating cytokines are not yet available, our recent studies in aged mice demonstrate that 1) age- associated epidermal dysfunction stimulates cutaneous pro-inflammatory cytokine production, accounting elevations in circulating cytokine levels, independent of liver or T-cell contributions; and 2) approaches that improve epidermal function reduce not only cutaneous, but also circulating cytokine l evels.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidermal Structure and Barrier Function Source Type: research