852 Short-term ozone exposure stimulates both IGF1R and EGFR to promote diabetic wound healing

Ozonated oil, containing the potent disinfectant and oxygen donor ozone (O3), improves wound oxygenation and closure after topical application. However, the mechanism of O3 action on skin cells during wound healing is largely unknown. We hypothesized that IGF1R/EGFR crosstalk and activation of downstream signaling pathways are required for the observed acceleration in wound healing. In a diet-induced obese diabetic mouse model, topical application of O3 oil visibly promoted healing with a 2-3-fold reduction in the epidermal gap and 1.7-fold increase in granulation tissue compared with vehicle-treated mice at 8 days after initiation (when wounds in nondiabetic mice had closed).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Growth Factors, Cell Adhesion and Matrix Biology Source Type: research