899 Various pro-inflammatory stimuli, including particulatematter pollution, induce hyperpigmentation in 3Dreconstructed skin models in vitro

Skin pigmentation is a tightly regulated process that can be modulated via internal and external stimuli. Extrinsically, the skin often is exposed to environmental stimuli and stresses such as solar UV and infrared light, as well as to environmental pollution, all of which are able to modulate skin pigmentation. Post-inflammatory hyperpigmentation (PIH) is a common, acquired pigmentary disorder caused by inflammatory dermatoses (including acne-related hyperpigmentation), infections, reaction to drugs, dermatologic procedures, and external injury (burns, frictions, trauma).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research