978 Enhanced platelet-activating factor synthesis facilitates acute and delayed effects of intoxicated thermal burn injury

Patients who suffer thermal burn injuries while intoxicated with ethanol (approximately half of all severe injuries) experience more complications, longer hospital stays, and almost twice the mortality than non-intoxicated burn patients. Murine models of intoxicated thermal burn injury have revealed that the injury manifests with an acute pro-inflammatory response and delayed immunosuppression but the mechanisms driving these effects are still unclear. The lipid mediator Platelet-activating factor (PAF) promotes inflammation and immunosuppression in response to skin injury but it has not been characterized in intoxicated thermal burn.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research