980 Oral tolerance induction in murine model of food allergy caused by epicutaneous sensitization

Recent studies suggest that the sensitization to food allergens commonly occur through the skin. We previously established a mouse model of epicutaneous sensitization using ovalbumin (OVA). BALB/c mice are sensitized by three-time application of OVA to tape-stripped skin (1-week sensitization at 2-week intervals) and oral challenge of OVA undertaken. Allergic symptoms such as fall of rectal temperature are observed after oral challenge (Yu R et al, Experimental Dermatology. 2017;26:778-784). In the present study, we examined whether oral administration of food is effective for the prevention and treatment of food allergy caused by epicutaneous sensitization using this murine model.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research