1024 Dissecting the molecular interdependence of skin inflammation and obesity

Psoriasis, a chronic inflammatory skin disease, is often compromised by comorbidities with obesity being the most prevalent. Epidemiological studies clearly associate obesity with psoriasis. The aim of the present study was to investigate how obesity alters skin immune responses. To this end, an obesity model was established by feeding of male C57Bl/6J mice with high-fat diet (HFD, 60% fat). To investigate the effect of obesity on Th17/Th1-mediated skin inflammation, a mouse model of 2,4,6-trinitrochlorobenzene (TNCB) contact hypersensitivity (CHS) was used.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research