1176 Mechanistic analysis of B16F10 melanoma cell death induced by treatment with recombinant TRAIL and bortezomib

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces caspase-dependent apoptosis in cancer cells after binding to its corresponding receptors. Previously, we demonstrated that a recombinant human TRAIL, ILz:rhTRAIL, potentiated TRAIL killing activity by multimerization through its isoleucine zipper hexamerization motif in human colon carcinoma and leukemic T lymphocytes. Additionally, treatment of tumor cells with the proteasome inhibitor bortezomib results in multiple biological effects including inhibition of the cell cycle and increased apoptosis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research