1291 PPAR- γ signaling is dysregulated in keloids

Keloids are exuberant scars in which overgrowths of fibrous tissue extend beyond the borders of the original skin injury. Traumatic insults that can lead to keloids include surgery, piercings, acne, insect bites, and even mild abrasions. These lesions do not regress, and can cause pain, pruritus and psychosocial effects when they appear. Pathway analysis of whole transcriptome data obtained from comparing RNA expression between matched keloid and normal tissue suggests that the PPAR γ signaling pathway may be dysregulated in keloids.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin of Color Source Type: research