1431 Neutralizing α-toxin accelerates healing of Staphylococcus aureus-infected wounds in normal and diabetic mice

Staphylococcus aureus wound infections delay healing and result in invasive complications such as osteomyelitis, especially in the setting of diabetic foot ulcers. In preclinical animal models of S. aureus skin infection, antibody neutralization of α-toxin (AT), a S. aureus secreted pore-forming cytolytic toxin, reduces disease severity by inhibiting skin necrosis and restoring effective host immune responses. However, whether therapeutic neutralization of α-toxin is effective against S. aureus-infected wounds is unclear.

Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: R. Ortines, H. Liu, L. Cheng, T. Cohen, H. Lawlor, A. Gami, Y. Wang, C. Dillen, N. Archer, R. Miller, A. Ashbaugh, B. Pinsker, M. Marchitto, C. Tkaczyk, C. Stover, B. Sellman, L. Miller Tags: Tissue Regeneration and Wound Healing Source Type: research