1449 Recombinant TSG-6 restores defects in inflammation during cutaneous wound healing in TSG-6 null mice

Inflammation plays an important role in cutaneous wounds. Disruption of the normal influx and resolution of inflammatory cells can lead to impaired wound healing in diabetes and other pathological conditions. Tumor necrosis factor stimulated gene-6 (TSG-6) is an enzyme that transfers heavy chains (HC) from inter-a-trypsin inhibitor (IaI) to hyaluronan (HA), forming HC-HA complexes (HC-HA) that are associated with various inflammatory conditions such as arthritis, asthma, and colitis. TSG-6 is thought to play important roles in neutrophil recruitment and macrophage polarization, two events critical to proper wound healing.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Tissue Regeneration and Wound Healing Source Type: research