Direct Access to Aryl Bis(trifluoromethyl)carbinols from Aryl Bromides or Fluorosulfates via a Pd-Catalyzed Carbonylation.

Direct Access to Aryl Bis(trifluoromethyl)carbinols from Aryl Bromides or Fluorosulfates via a Pd-Catalyzed Carbonylation.
Angew Chem Int Ed Engl. 2018 Apr 17;:
Authors: Skrydstrup T, Domino K, Veryser C, Wahlqvist B, Gaardbo C, Neumann KT, Daasbjerg K, De Borggraeve W
Abstract
A Pd-catalyzed carbonylative approach for the direct conversion of (hetero)aryl bromides into their α,α-bis(trifluoromethyl)carbinols is described, applying only stoichiometric amounts of carbon monoxide and trifluoromethyltrimethyl-silane. In addition, aryl fluorosulfates proved highly compatible to these reaction conditions. The method is tolerant of a diverse set of functional groups, and it is adaptable to late-stage carbon isotope labeling.
PMID: 29663685 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - April 17, 2018 Category: Chemistry Authors: Skrydstrup T, Domino K, Veryser C, Wahlqvist B, Gaardbo C, Neumann KT, Daasbjerg K, De Borggraeve W Tags: Angew Chem Int Ed Engl Source Type: research