Age-adjusted global glomerulosclerosis in addition to Oxford histological classification of IgA nephropathy

We thank Hommos et  al. for their robust study that found that only globally sclerotic glomeruli (GSG) exceeding the age-specific 95th percentile for global glomerulosclerosis in healthy adults was associated with progressive chronic kidney disease in glomerulopathies presenting with nephrotic syndrome.1 Earlier, we demonstrated that extent of GSG was independently associated with end-stage renal disease at 30 years in a young cohort (median age, 25 years; interquartile range, 21–30 years) that did not receive immunosuppressants when diagnosed with IgA nephropathy (IgAN) in the 1970s and early 1980s.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research