Hormone replacement therapy, mammographic density, and breast cancer risk: a cohort study

ConclusionsMD partially mediates some of the association between HRT and breast cancer risk. The association between HRT and breast cancer seems to be stronger in women with dense breasts.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research

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ConclusionBreast density is an independent and significant risk factor for development of contralateral breast cancer. This risk factor should contribute to clinical decision making.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionThe risk prediction model indicates that the following variables should be assessed in this specific population: age, height, having had previous breast biopsies, number of pregnancies, and use of hormone replacement therapy. These findings may help to better understand the causal model of breast cancer in Southern Brazil.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Conclusion: These data indicate that TBBPA, triclosan, and BPA interact in vivo, consistent with evidence that TBBPA and triclosan inhibit enzymes that are critical for BPA and E2 metabolism. https://doi.org/10.1289/EHP1329 Received: 04 November 2016 Revised: 11 April 2017 Accepted: 13 April 2017 Published: 21 August 2017 Address correspondence to D. deCatanzaro, Dept. of Psychology, Neuroscience &Behaviour, McMaster University, 1280 Main St. West, Hamilton ON L8S 4K1, Canada. Telephone: (905) 525-9140, ext. 23014. Email: decatanz@mcmaster.ca Supplemental Material is available online (https://doi.org/10.1289/EHP1...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
ConclusionsWe confirm in this Mediterranean population the association of increasing MBD, classified according to BI-RADS with BC risk also taking into account other well-known risk factors for this neoplasm.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
AbstractPrevious studies have linked reductions in mammographic density after a breast cancer diagnosis to an improved prognosis. These studies focused on short-term change, using a 2-stage process, treating estimated change as a fixed covariate in a survival model. We propose the use of a joint longitudinal-survival model. This enables us to model long-term trends in density while accounting for dropout as well as for measurement error. We studied the change in mammographic density after a breast cancer diagnosis and its association with prognosis (measured by cause-specific mortality), overall and with respect to hormone...
Source: American Journal of Epidemiology - Category: Epidemiology Source Type: research
CONCLUSIONS: COMT Val158Met polymorphism may be associated with mammographic density at least in healthy women. Menopausal status and HRT should be taken into account in future studies to avoid masking of the underlying effects. PMID: 28473194 [PubMed - as supplied by publisher]
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
ConclusionsBreast MRI provides greater accuracy for a third of patients undergoing preoperative MGM and U/S. Mammographic calcifications were associated with MRI clinical accuracy for patients with invasive cancer.
Source: Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research
Publication date: Available online 24 March 2017 Source:Journal of Cancer Policy Author(s): Bassam Ahmed Almutlaq, Rakan Fraih Almuazzi, Ahmed Abdullah Almuhayfir, Abdulrhman Mutlaq Alfouzan, Bandar Turqi Alshammari, Haitham Samear AlAnzi, Hussain Gadelkarim Ahmed Breast cancer is the commonest females’ cancer and the leading cause of cancer death worldwide. There is a substantial rise in the incidence of breast cancer in Saudi Arabia in recent years, particularly among younger females compared to affected females’ in western countries. There have been several factors implicated to the etiology of breast cance...
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
Background: Studies have demonstrated that use of hormone replacement therapy (HRT) in post-menopausal women results in increased breast density. This is associated with increased risk of breast cancer and reduced sensitivity of mammography. The purpose of the present study was to compare breast densities of women following surgical menopause with and without use of HRT to women who had natural menopause without use of HRT.Methods: Our institutional Database was queried for post-menopausal women newly diagnosed with breast cancer from 01/2010 to 01/2016. Patients were divided into following groups: 1) natural menopause wit...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
Conclusions. Our model includes three mammographic features that could easily be derived from clinically available software. By adding information on some few established risk factors it is possible to improve clinical care by identifying women in need of additional examination procedures. At the same time there is a substantial proportion of women that will have very little benefit from mammography screening due to their low risk of breast cancer.canres;77/4_Supplement/P4-03-16/table1T1Table 1. Absolute 2-year risk of breast cancer in women stratified in to risk categories based on the NICE guidelinesAbsolute 2-year risk ...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
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