Improved method of delivering anti-cancer drugs

(Cardiff University) A new non-toxic method for delivering anti-cancer drugs to specific parts of the human body could mean the end of the severe and nasty side effects associated with many cancer therapies, according to researchers at Cardiff University's School of Pharmacy and Pharmaceutical Sciences.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Zhou Y, Li N, Qiu Z, Lu X, Fang M, Chen X, Ren L, Wang G, Ouyang P Abstract Triacontanol (TA, C30H62O), abundantly present in plant cuticle waxes and bee waxes, has been found to display promising anti-neoplastic potentials. As a long chain fatty alcohol, TA possesses limited aqueous solubility, which hinders its medicinal application. To overcome its solubility barrier, a polymer prodrug was synthesized through attaching TA to poly ethylene glycol (PEG), using succinic acid as a linker with bifunctional amide and ester bonds. Anti-neoplastic effects of PEG-TA were assessed in LoVo and MCF7 cells, anti-pro...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
ConclusionWithin an evolving context where services are centralised, new therapies emerge and subsequently come off patent, our understanding of the value of cancer therapies continues to evolve. This has important implications for the evaluation of new therapies and broader policy initiatives in this area.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Marjan Ghorbani, Hamed HamishehkarAbstractThe clinical applications of anticancer drugs are restricted due to the incomplete delivery to the cancerous tissue and the numerous drug resistance mechanisms involved in malignant cells. In this regard, stimuli-responsive nanomaterials offer a promising prospect to deal with these concerns. In the present study, ternary responsive hybrid gold/nanogels (Au/NGs) were synthesized as a new nanoplatform to simultaneously carry two anticancer drugs, i.e., doxorubicin (DOX) and 6-mercaptop...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In conclusion, our novel formulation destabilized H358 cells by using its acidic tumor microenvironment, thereby regulating cell apoptosis, proliferation, and metastatic properties.
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Yuanfang Huang, Ping Xie, Sheng-Tao Yang, Xuemei Zhang, Guangfu Zeng, Qian Xin, Xiao-Hai TangAbstractDrug delivery systems for doxorubicin (DOX) have attracted tremendous interest nowadays for the improved efficacy and/or reduced toxicity. Due to the aromatic structures and hydrophobic domains, carbon nanoparticle suspension injection (CNSI), a clinical applied reagent for lymph node mapping, strongly adsorbs DOX and holds great potential in cancer therapy. Herein, we evaluated the therapeutic effects of CNSI-DOX to establish...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, novel molecularly imprinted polymer (MIP) microparticles containing methacryl polyhedral oligomeric silsesquioxane (M-POSS) were synthesized through the RAFT precipitation polymerization (RAFTPP) method using paclitaxel (PTX) as the templates. During the course of this investigation, methacrylic acid (MAA) was used as the functional monomer, while ethylene glycol dimethacrylate (EGDMA) was utilized as a cross-linker. The effects of different molar ratios of M-POSS on the microparticles were characterized. The obtained MIP microparticles were confirmed by FT-IR and TGA-DSC. The results of SEM showed regular s...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Chem. Commun., 2018, Advance Article DOI: 10.1039/C8CC03720E, CommunicationLei Xing, Jia-Liang Zhang, Tian-jiao Zhou, Yu-Jing He, Peng-Fei Cui, Jia-Hui Gong, Minjie Sun, Jin-Jian Lu, Zhangjian Huang, Liang Jin, Hu-Lin Jiang A polynuclear nanoparticle fabricated through a sequential hydrophobic and electrostatic interaction mechanism can circumvent the contradictory problem of siRNA binding capacity and toxicities of cationic vectors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
FRIDAY, July 20, 2018 -- Patients with cancer who receive complementary medicine (CM) are more likely to refuse conventional cancer treatment (CCT), according to a study published online July 19 in JAMA Oncology. Skyler B. Johnson, M.D., from the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Publication date: Available online 19 July 2018Source: Cancer CellAuthor(s): Lingtao Jin, Jaemoo Chun, Chaoyun Pan, Dan Li, Ruiting Lin, Gina N. Alesi, Xu Wang, Hee-Bum Kang, Lina Song, Dongsheng Wang, Guojing Zhang, Jun Fan, Titus J. Boggon, Lu Zhou, Jeanne Kowalski, Cheng-Kui Qu, Conor E. Steuer, Georgia Z. Chen, Nabil F. Saba, Lawrence H. BoiseSummaryPlatinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance limits their curative potential. Through a kinome RNAi screen, we identified microtubule-associated serine/threonine kinase 1 (MAST1) as a main driver of cisplatin resistance in human ca...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Authors: Blagodatski A, Yatsunskaya M, Mikhailova V, Tiasto V, Kagansky A, Katanaev VL Abstract Medicinal mushrooms have been used throughout the history of mankind for treatment of various diseases including cancer. Nowadays they have been intensively studied in order to reveal the chemical nature and mechanisms of action of their biomedical capacity. Targeted treatment of cancer, non-harmful for healthy tissues, has become a desired goal in recent decades and compounds of fungal origin provide a vast reservoir of potential innovational drugs. Here, on example of four mushrooms common for use in Asian and Far East...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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