The Role of IRE1 Signaling in Central Nervous System Diseases.

The Role of IRE1 Signaling in Central Nervous System Diseases. Curr Neuropharmacol. 2018 Apr 15;: Authors: Ni H, Rui Q, Li D, Gao R, Chen G Abstract The accumulation of misfolded or unfolded proteins in endoplasmic reticulum (ER) lumen results in activation of an adaptive stress process called the unfolded protein response (UPR). As the most conserved signaling branch of the UPR, Inositol-requiring enzyme 1 (IRE1) possesses both Ser/Thr kinase and RNase activities that operates as a major stress sensor, mediating both adaptive and pro-apoptotic pathways under ER stress. Over the last three decades, a mounting body of evidence has shown that IRE1 signaling dysfunction is involved in pathology of various neurological disorders. Targeting this pathway has emerged as a promising therapeutic strategy against these diseases. In this review, we provide a general overview about the expression and physiological function of IRE1 signaling and its pathophysiological roles in central nervous system diseases. PMID: 29663887 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research