Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes

Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypesMitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes, Published online: 18 April 2018; doi:10.1038/s41584-018-0001-0Mitochondrial dysfunction and mitochondrial DNA (mtDNA) influence several molecular processes underlying the pathogenesis of osteoarthritis (OA), and mtDNA variants are associated with the development and progression of knee OA, pointing to a role for mtDNA variation in OA pathogenesis and its phenotypic presentation.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research