Reply to Commentary on ‘HER2 immunohistochemical and fluorescence in situ hybridization discordances in invasive breast carcinoma with micropapillary features’

Reply to Commentary on ‘HER2 immunohistochemical and fluorescence in situ hybridization discordances in invasive breast carcinoma with micropapillary features’Reply to Commentary on ‘HER2 immunohistochemical and fluorescence in situ hybridization discordances in invasive breast carcinoma with micropapillary features’, Published online: 18 April 2018; doi:10.1038/modpathol.2018.28Reply to Commentary on ‘HER2 immunohistochemical and fluorescence in situ hybridization discordances in invasive breast carcinoma with micropapillary features’
Source: Modern Pathology - Category: Pathology Authors: Source Type: research

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Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: 15 January 2020Source: Journal of Molecular Structure, Volume 1200Author(s): Ahmed H. Halawa, Essam M. Eliwa, Ahmed A. Hassan, Hesham S. Nassar, R.A. El-Eisawy, Mohamed Ismail, Marcel Frese, Mohamed Shaaban, Ahmed M. El-Agrody, Ahmed H. Bedair, Norbert SewaldAbstractA new series of 4-arylamino-3-nitrocoumarin analogues (4–18) have been synthesized and characterized by sophisticated spectroscopic techniques (1H NMR, 13C NMR) and mass spectrometry. All the new synthesized compounds were evaluated for their in vitro cytotoxic activity against the human cervix carcinoma cell line (KB-3-1) using res...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Conclusions: In case of small, low-risk IBTR, adjuvant re-irradiation using multi-catheter brachytherapy is a feasible, safe, and effective treatment method after repeated lumpectomy, and an alternative to mastectomy. PMID: 31523231 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Abstract Micropapillary carcinoma of the bladder (MPBC) is a variant type of infiltrating urothelial carcinoma, which portends a poor biological behavior in terms of disease stage at first diagnosis and clinical outcome; its peculiar morphology raises issues concerning the ability of tumor detection by imaging techniques and proper biopsy procedure, and the appropriate treatment for non-muscle infiltrating and muscle-infiltrating MPBC remains a matter of debate. On the basis of its established prognostic and therapeutic role in breast and gastro-esophageal cancer in the first instance, the human epidermal growth f...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
In this study, we sought to analyze the expression of HER2 in a large cohort of micropapillary UCA. A search was performed through our Urologic Pathology files and expert consult files of the senior author for cases of micropapillary UCA of the bladder. Twenty-seven cases were identified.
Source: Human Pathology - Category: Pathology Authors: Tags: Original contribution Source Type: research
ConclusionSalivary duct carcinoma demonstrates a wide histopathologic spectrum. Treatment strategies need to take androgen receptor, HER2 amplification, and PIK3CA mutation into account. © 2015 Wiley Periodicals, Inc. Head Neck, 2015
Source: Head and Neck - Category: ENT & OMF Authors: Tags: Original Article Source Type: research
Abstract Invasive micropapillary carcinoma of breast (IMpC) is a special type of breast cancer with frequent lymph node metastasis (LNM) and poor prognosis, while pure mucinous carcinoma of breast (PMC) is generally associated with infrequent LNM and better prognosis. A similar micropapillary epithelial growth pattern has been described in PMC that was named as invasive micropapillary mucinous carcinoma (IMpMC), but its prognostic significance is as yet not known. A retrospective review of 531 cases of PMC in 43,685 cases of breast cancer diagnosed over a 10-year period was conducted to assess the frequency of IMp...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Proteases constitute a large family of enzymes involved in several processes, including degradation and remodeling of the extracellular matrix to drive dissemination of cancer cells into adjacent tissue. Within this large family, the serine protease neutrophil elastase (NE) has been proven clinically meaningful in breast cancer. Indeed, high levels of NE correlate with poor outcome and endocrine resistance in breast cancer patients. In an experimental model it has been demonstrated that estrogen receptor positive (ER+) MCF7 breast cancer cells grow in suspension as 3D-spheroids in NE-addicted medium, thus resembling the mi...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
AbstractObjectiveThe purpose of this study was to study the clinical and pathological characteristics of breast intraductal proliferative lesions (IDPLs) and associated with invasive breast cancer.MethodsWe reviewed 327 cases of breast intraductal proliferative lesions including 53 cases of usual ductal hyperplasia, 57 cases of atypical ductal hyperplasia, 89 cases of ductal carcinoma in situ, and 128 cases coexist with invasive ductal carcinomas. Cases of pure invasive cancer without intraductal proliferative lesions were excluded. The mult IDPLs biological parameters including the express of ER, PR, HER2, HIF-1 α a...
Source: The Chinese-German Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
-Micropapillary breast carcinoma (or invasive micropapillary carcinoma IMPC) is a type of otherwise 'typical' invasive ductal carcinoma which exhibits a unique and characteristic growth pattern. -Invasive micropapillary breast carcinoma is a very aggressive form of breast cancer, with a very high rate of lymph node metastasis.(The rate of lymph node involvement is estimated at between 75% and 100%).-Skin invovlement (skin retraction) is another occassional feature of invasive micropapillary carcinoma of the breast, and is observed in about 20-23% of all cases.Histological aspects of invasive micropapillary carcinoma o...
Source: Oncopathology - Category: Cancer & Oncology Tags: breast breast cancer carcinoma micropapillary poor prognosis Source Type: blogs
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