How chemotherapy induces infertility

Researchers have described the mechanism that explains infertility in women who undergo chemotherapy, a study inNature Structural& Molecular Biology suggests.Science Daily
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Conclusion: Niacin may have an important function in treating POF by reducing apoptosis in clinical applications.Cell Physiol Biochem 2018;50:2060 –2070
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Authors: Cui W, Stern C, Hickey M, Goldblatt F, Anazodo A, Stevenson WS, Phillips KA Abstract Alkylating chemotherapy is often used to treat pre-menopausal women for various malignancies and autoimmune diseases. Chemotherapy-associated ovarian failure is a potential consequence of this treatment which can cause infertility, and increases the risk of other long term adverse health sequelae. Randomised trials, predominantly of women undergoing alkylating chemotherapy for breast cancer, have shown evidence for the efficacy of gonadotropin-releasing hormone agonists (GnRHa) in preventing chemotherapy-associated ovarian...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
AbstractChemotherapy-induced gonadal dysfunction resulting in transient or persistent infertility depends on the type of drugs and cumulative dose, and it is an important long-term complication, especially for adolescent and young adult (AYA) cancer patients. Due to its importance, a clinical practice guideline for fertility preservation in childhood and AYA cancer patients was published by the Japan Society of Clinical Oncology (JSCO) in 2017. Although the precise mechanisms remain unclear, several studies reported that the cancer itself, not the cancer treatment, adversely affected semen quality. It is reported that that...
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
(Natural News) Conventional treatments for cancer, such as chemotherapy and radiation, are known for targeting even healthy cells. The damage induced on healthy cells by non-selective targeting these cancer treatments lead to side effects like diarrhea, anemia, infertility, mood changes, and weight loss. To avoid these side effects, people are now turning to traditional medicine...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Treatment for cancer and other serious conditions involves toxic chemotherapy drugs, radiation and surgery that can cause infertility in women and men.
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Conclusion: The patients of SLCT can present with hormonal magnification and manifest high AFP, CA125, and T levels. SLCT is characterized by a solid or mixed solid-cystic mass on CT/MR scans, and shows marked or moderated heterogeneous and constantly enhancement upon postcontrast study. The clinical characteristics and imaging findings are features and appropriated imaging should be performed whenever an SLCT is suspected.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
We report a case of a 42-year-old woman with a history of bilateral ductal carcinoma of the breast who underwent radical mastectomy with chemotherapy and radiotherapy was anxious to conceive. In vitro fertilization was performed with donor oocyte; the patient became pregnant and delivered a full term baby with no congenital anomalies. As very few have a background for providing guidance and treatment in this setting, this report highlights the possibility of improving the quality of reproductive life of young survivors by various assisted reproductive techniques, the importance of fertility preservation and a multidisciplinary team approach.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
This article discusses these exciting new developments in the treatment of advanced-stage Hodgkin lymphoma.
Source: The Cancer Journal - Category: Cancer & Oncology Tags: Review Articles Source Type: research
This article discusses these exciting new developments in the treatment of advanced-stage Hodgkin lymphoma. PMID: 30247258 [PubMed - in process]
Source: Cancer Journal - Category: Cancer & Oncology Authors: Tags: Cancer J Source Type: research
Abstract Cancer patients' quality of life is greatly dependent on the efficacy of treatments and their associated side effects, which can significantly reduce the overall quality of life. Although the effectiveness of cancer treatments has improved over time, adverse effects persist with each treatment. Some side effects, such as paclitaxel-induced peripheral neuropathy, can be dose limiting, thus further reducing the potential of paclitaxel chemotherapy treatment. Premature ovarian failure in young female patients due to radiation and chemotherapy therapy can have devastating infertility consequences. In rec...
Source: Advances in Cancer Research - Category: Cancer & Oncology Authors: Tags: Adv Cancer Res Source Type: research
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