Synthesis of a deoxyguanosine monophosphate rich propyl methacrylate oligomer

We report on the first synthesis of a "protected" 5[prime or minute]-dimethoxytrityl-N-isobutyryl-2'-deoxyguanosine(dG), 3'-[(2-cyanoethyl)-2-(methacryloyloxy)propyl]-monophosphate monomer through a modified phosphoramidite coupling method. Here, 2-hydroxylpropyl methacrylate (HPMA) was coupled to a protected 5'-dimethoxytrityl-N-isobutyryl-2'-deoxyguanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Subsequent... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - New J. Chem. latest articles - April 18, 2018 Category: Chemistry Authors: Michael Wilson Source Type: research