Atropa belladonna neurotoxicity: Implications to neurological disorders.

Atropa belladonna neurotoxicity: Implications to neurological disorders. Food Chem Toxicol. 2018 Apr 10;: Authors: Kwakye GF, Jiménez J, Jiménez JA, Aschner M Abstract Atropa belladonna, commonly known as belladonna or deadly nightshade, ranks among one of the most poisonous plants in Europe and other parts of the world. The plant contains tropane alkaloids, including atropine, scopolamine, and hyoscyamine, which are used as anticholinergics in Food and Drug Administration (FDA) approved drugs and homeopathic remedies. These alkaloids can be very toxic at high dose. The FDA has recently reported that Hyland's baby teething tablets contain inconsistent amounts of Atropa belladonna that may have adverse effects on the nervous system and cause death in children, thus recalled the product in 2017. A greater understanding of the neurotoxicity of Atropa belladonna and its modification of genetic polymorphisms in the nervous system is critical in order to develop better treatment strategies, therapies, regulations, education of at-risk populations, and a more cohesive paradigm for future research. This review offers an integrated view of the homeopathy and neurotoxicity of Atropa belladonna in children, adults and animal models, as well as its implications to neurological disorders. Particular attention is dedicated to the pharmaco/toxicodynamics, pharmaco/toxicokinetics, pathophysiology, epidemiological cases, and animal studies associated with t...
Source: Food and Chemical Toxicology - Category: Food Science Authors: Tags: Food Chem Toxicol Source Type: research

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Abstract BACKGROUND:  The importance of temperament in the selection of an individualized homeopathic medicine has not been evaluated systematically. The current study explored this under-researched area. MATERIALS AND METHODS:  A prospective, open, randomized (1:1), two parallel arms, pilot trial was performed on patients suffering from various chronic diseases. Each patient's temperament was assessed using a newly developed "temperament diagnostic questionnaire". Outcome measures were health status using the EQ-5D-5L questionnaire and a visual analog scale (VAS) of patient's self-rated h...
Source: Homeopathy - Category: Complementary Medicine Authors: Tags: Homeopathy Source Type: research
May 14, 2019 -- The U.S. Food and Drug Administration has posted warning letters to five companies who produce products labeled as homeopathic for significant violations of current good manufacturing practice (CGMP) regulations. Four of the warning...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
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Source: Homeopathy - Category: Complementary Medicine Authors: Tags: Homeopathy Source Type: research
Condition:   Overweight and Obesity Interventions:   Drug: Homeopathic Medication;   Other: Multidisciplinary intervention (Exercise program, diet, motivational support);   Drug: Homeopathic placebo Sponsor:   Hospital Juarez de Mexico Recruiting
Source: - Category: Research Source Type: clinical trials
ConclusionWe provide new insights on factors that might increase the risk of serious AR associated with CAM use in children: products containing more than two components and simultaneously administered with conventional medications can represent a potential risk in children.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
PMID: 31060078 [PubMed - in process]
Source: Homeopathy - Category: Complementary Medicine Authors: Tags: Homeopathy Source Type: research
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Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS:  Aspirin 15 cH acts through the inhibition of the COX-2 pathway producing a clear pro-thrombotic effect. Further studies should clarify if the pro-thrombotic effect of aspirin withdrawal and the effect of aspirin 15 cH are related, as secondary effects of the same drug. Clarifying this last outcome may be of great significance to public health. PMID: 31005060 [PubMed - as supplied by publisher]
Source: Homeopathy - Category: Complementary Medicine Authors: Tags: Homeopathy Source Type: research
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Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Multidiscip Respir Med Source Type: research
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