Abstract 23: Lower Heart Rate Variability Associated With Incident Coronary Heart Disease and Death in Post-Menopausal Women Session Title: Predicting the Future

Conclusion: In post-menopausal women, lower HRV was associated with a modestly higher, but statistically significant, risk for incident cardiovascular events, including fatal and non-fatal myocardial infarction. Factors associated with lower HRV and cardiac autonomic impairment may be candidates for reducing CHD risk, such as better glycemic control and improved physical activity.
Source: Circulation: Cardiovascular Quality and Outcomes - Category: Cardiology Authors: Tags: Session Title: Predicting the Future Source Type: research

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ConclusionsThis study shows that reduction of CTRP3 concentrations is likely to bring a concomitant increase in risk of diabetes in obese and normal body weight young adults. Decrease in CTRP3 concentration may have an essential role in the pathophysiology of metabolic disorders concomitant to obesity.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 19 October 2018Source: Pharmacology &TherapeuticsAuthor(s): A.D. Dobrian, M.A. Morris, D.A. Taylor-Fishwick, T.R. Holman, Y. Imai, R.G. Mirmira, J.L. NadlerAbstract12-lipoxygenase (12-LOX) is one of several enzyme isoforms responsible for the metabolism of arachidonic acid and other poly-unsaturated fatty acids to both pro- and anti-inflammatory lipid mediators. Mounting evidence has shown that 12-LOX plays a critical role in the modulation of inflammation at multiple checkpoints during diabetes development. Due to this, interventions to limit pro-inflammatory 12-LOX metabolites eithe...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
ConclusionLack of drug efficacy, inappropriate drug adherence and patient knowledge were the major TRPs identified via delivering the MMR service to post-stroke patients. The identified TRPs highlights the importance of the MMR service, and supports planning future strategies aimed at decreasing the incidence of strokes.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
ConclusionThese findings suggest that the antihypertensive effect of MOE in L-NAME-hypertensive rats may be mediated by alleviating vascular dysfunction and oxidative stress and promoting endothelium-dependent vasorelaxation. MOE may be potentially useful as a natural product against hypertension.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 October 2018Source: Canadian Journal of CardiologyAuthor(s): Panagiotis Savvoulidis, Javed Butler, Andreas KalogeropoulosAbstractWith the advent and widespread use of antiretroviral therapy (ART), the epidemiology of cardiomyopathy and heart failure (HF) associated with human immunodeficiency virus (HIV) infection is changing. Near-normal life expectancy in contemporary HIV-infected populations has been associated with prolonged exposure to increased cardiometabolic burden and chronic immune activation and systemic inflammation. Therefore, the pre-ART phenotype of HIV-associated cardio...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 19 October 2018Source: Canadian Journal of CardiologyAuthor(s): Janek M. Senaratne, Colleen M. Norris, Erik Youngson, Robert S. McClure, Jayan Nagendran, Craig R. Butler, Steven R. Meyer, Todd J. Anderson, Sean Van DiepenAbstractBackgroundCardiac surgery waitlist recommendations, which were developed based on expert opinion, poorly predict pre-operative mortality. Studies reporting risk factors for waitlist mortality have not evaluated the risks including non-adherence to waitlist benchmarks.MethodsIn patients who underwent cardiac surgery or died on the waitlist between 2005 and 2015, we...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 19 October 2018Source: American Heart JournalAuthor(s): William J Davison, Phyo Kyaw Myint, Allan B Clark, John F PotterAbstractBackgroundGuidelines recommend ambulatory or home blood pressure monitoring to improve hypertension diagnosis and monitoring. Both these methods are ascribed the same threshold values, but whether they produce similar results has not been established in certain patient groups.MethodsAdults with mild/moderate stroke or transient ischaemic attack (N=80) completed two sets of ambulatory and home blood pressure monitoring. Systolic and diastolic blood pressure values...
Source: American Heart Journal - Category: Cardiology Source Type: research
In this study, glibenclamide silica monolithic xerogel implants for subdermal application (GMSIx) were developed using the sol-gel technique for matrix synthesis with TEOS with different drying conditions (environmental, 60, 90, and 120 °C, which were named as GMSIE, GMSI60, GMSI90, and GMSI120, respectively). The inclusion of the drug in monoliths was monitored by DSC, FTIR, and PXRD. The effect of drying conditions on the morphology, moisture content, hardness, dosage uniformity, surface characteristics, and drug release mechanism of glibenclamide from the matrices was systematically investigated. Oral Glucose Tole...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 19 October 2018Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Rafal Rygula, Karolina Noworyta-Sokolowska, Robert Drozd, Anna KozubAbstractDepressive disorder accounts for a substantial proportion of psychiatric problems across the globe and has a devastating impact on quality of life and occupational function. Psychological models of depression emphasize the causal role of cognitive distortions in this disease, and cognitive problems have been included in the diagnostic criteria for depressive episodes. Here, we focus on recent progress in preclinical modelling of aberrations i...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Publication date: Available online 19 October 2018Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Aleksandra M. Herman, Theodora DukaAbstractAlcohol misuse is a major public concern. Impulsivity has been recognised as a significant risk factor predisposing for the initiation of alcohol use, continuation and excessive alcohol use. Evidence suggests that impulsivity is also a result of both acute alcohol intoxication and long-term alcohol abuse. The multifaceted character of impulsivity and the various ways of assessing it in humans and animal models, hampers the full understanding of how impulsivity relates to alc...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
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