Buprenorphine Depresses Respiratory Variability in Obese Mice with Altered Leptin Signaling

Conclusions The results support the interpretation that leptin status but not body weight or sex contributed to the buprenorphine-induced decrease in minute ventilation. Poincar é plots illustrate that the buprenorphine-induced decrease in minute ventilation variability was greatest in mice with impaired leptin signaling. This is relevant because normal respiratory variability is essential for martialing a compensatory response to ventilatory challenges imposed by disease, obesity, and surgical stress.
Source: Anesthesiology - Category: Anesthesiology Source Type: research