Spectrum of biopsy-proven renal diseases: A single center experience.
This study included 271 consecutive percutaneous kidney biopsies (145 males and 126 females) performed at EMS Memorial Cooperative Hospital, Perinthalmanna, Kerala, India, from September 2009 to March 2016. Among the biopsy-proven renal diseases (BPRD), primary glomerular diseases (PGD) were the most common (77.78%) followed by secondary glomerular diseases (SGD) (12.22%) and tubulointerstitial diseases (10%). The IgA nephropathy (IgAN) was the most common PGD and majority had mesangial hypercellularity (M1) (93.54%), tubular atrophy (T1 or T2 68.25%), and the most common pattern was M1, E0, S0, and T1, suggesting that patients of Indian subcontinent have aggressive disease type, unlike western literature. The focal segmental glomerulosclerosis (FSGS) was the second most common PGD and the majority were of not otherwise specified type. FSGS, membranous nephropathy and minimal change disease were the three most common causes for PGD causing nephrotic syndrome. Diabetic nephropathy and lupus nephritis were the two most common biopsy-proven SGDs. Among the patients of diabetes mellitus who underwent renal biopsy with suspicion of nondiabetic renal disease (NDRD), 58.33% had NDRD, 16.67% had DN+ NDRD, and 26.67% had DN alone. This study shows the changing pattern BPRD in comparison to earlier studies. This study also confirms the aggressive nature of IgAN in Indian patients and underlines the importance of renal biopsy in patients of DM. PMID: 29657209 [PubMed - in process]
The evidence for cardiovascular risk stratification in kidney transplant recipients is lacking in this population. Might more field-specific research help bridge the gap?Nephrology Dialysis Transplantation
In what ways has the use of increased risk donors impacted the outcomes of pediatric kidney transplants?American Journal of Transplantation
ConclusionsFor patients with Type 2 diabetes, team-based care improves blood glucose, blood pressure, and lipid levels.
Publication date: July 2019Source: American Journal of Preventive Medicine, Volume 57, Issue 1Author(s): Community Preventive Services Task Force
Publication date: Available online 17 June 2019Source: International Journal of Pediatrics and Adolescent MedicineAuthor(s): Kahlid Alshaigi, Reema Albraheem, Khalid Alsaleem, Moneer Zakaria, Aman Jobeir, Hesham AldhalaanAbstractBackgroundThe autism spectrum disorder (ASD) diagnosed children have social and cognitive disabilities. For parents, these behaviors can lead to humiliation, social exclusion and isolation. Stigma is a problem that not only may affect the individual with high functioning autism, but has the potential to extend to their family as well. Indeed, research indicates that the parents of children with dis...
Oil firms are said to have known for decades of the link between burning fossil fuels and climate breakdown. Author Bill McKibben describes how industry lobbying created a 30-year barrier to tackling the crisis. Plus: John Stewart on his campaign to stop the third runway at HeathrowBefore 1988,climate change was a subject confined to the realm of academic journals. That all changed when the scientist James Hansen told Congress that global heating was caused by the buildup of greenhouse gases in the atmosphere as a result of the burning of fossil fuels.That moment caught the imagination of the journalistBill McKibben,who ha...
Publication date: July 2019Source: Trends in Endocrinology &Metabolism, Volume 30, Issue 7Author(s): Naila Rabbani, Paul J. ThornalleyHexokinase-2 (HK2) was recently found to produce increased metabolic flux through glycolysis in hyperglycemia without concurrent transcriptional or other functional regulation. Rather, stabilization to proteolysis by increased glucose substrate binding produced unscheduled increased glucose metabolism in response to high cytosolic glucose concentration. This produces abnormal increases in glycolytic intermediates or glycolytic overload, driving cell dysfunction and vulnerability to the d...
Publication date: Available online 17 June 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s):