Colistin-induced myasthenic syndrome in a patient with end-stage renal disease.

Colistin-induced myasthenic syndrome in a patient with end-stage renal disease. Saudi J Kidney Dis Transpl. 2018 Mar-Apr;29(2):435-439 Authors: Sengupta P, Biswas S Abstract With resurgence of multidrug resistance (MDR) bacteria and no new novel broad-spectrum antibiotic in research pipeline, usage of older generation antibiotics, once discarded due to their toxicity profile are becoming popular again. Often these drugs are the only option left in managing MDR bacteria-related sepsis. Colistin is one of such antibiotic which is often used in recent times after decades of its avoidance due to its diverse toxicity profile. In this case report, we present a rare myasthenic syndrome like neuromuscular complication developed in a patient after receiving colistin for treatment of MDR Klebsiella-related urosepsis. PMID: 29657216 [PubMed - in process]
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research

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Publication date: Available online 15 June 2019Source: Saudi Journal of Biological SciencesAuthor(s): Mohamed A. Al-Shehri, Mohamed A. El-Sheikh, Ahmed H. Al-Farhan, Ibrahim A. Arif, R. Rajakrishnan, Abdulrahman A. Alatar, Mohammad Faisal, Riyad A. Basahi, Ghanim A. Al-AbbadiAbstractThe wild Prunus korshinskyi has a restricted distribution in small scattered areas of Jabal Al-Lauz (2580 m above sea level), a mountain in northwestern Saudi Arabia. Major objective of current study is to provide information about P. korshinskyi by analyzing its ecology in terms of floristic diversity, plant associations, environmental feature...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
In this study, whole genome comparative genomic hybridization array (array CGH) based genomic analysis was performed on twelve Saudi Lynch syndrome patients. A total of 124 chromosomal alterations (structural loss) were identified at mean log2 ratio cut off value of ±0.25. We also found structural loss in 2p21-p16.3, 3p23-p14.2, 7p22.1 and 1p34.1-p33 regions. These findings were subsequently validated by real time quantitative PCR showing downregulation of MSH2, MSH6, EPCAM, MLH1, PMS2 and MUTYH genes. These findings shall help in establishing database for alterations in mismatch repair genes underlying Lynch syndro...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
This study investigated the effect of Indonesian propolis wax from Tetragonula sp as a therapy in limited vaginal candidiasis patients. The subjects were women who came to the Tasik Community Health Centre met the inclusion criteria such as clinical complaint and laboratory evaluation (positive hyphae/pseudohyphae and culture on Sabouraud Dextrose Agar (SDA) medium) from a vaginal swab. Evaluation of anti-candida effect of propolis was determined by clinical remission and the absence of Candida’s growth on SDA medium. Forty subjects were randomly assigned to those receiving treatment by ovule propolis (n=20) and...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Authors: Hasbal NB, Koc Y, Sevinc M, Unsal A, Basturk T PMID: 31201047 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
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Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 15 June 2019Source: The SurgeonAuthor(s): Ming He, David Talbot
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Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
ConclusionsDistribution of NDM variants among E. coli strains is a serious threat to global public health. In addition, the most prevalent E. coli clonal groups such as ST101 and ST167 are one of the main causes of E. coli infection in different countries.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
e C Abstract The zebrafish is a powerful vertebrate model for genetic studies on embryonic development and organogenesis. In the last decades, zebrafish were furthermore increasingly used for disease modeling and investigation of cancer biology. Zebrafish are particularly used for mutagenesis and small molecule screens, as well as for live imaging assays that provide unique opportunities to monitor cell behavior, both on a single cell and whole organism level in real time. Zebrafish have been also used for in vivo investigations of human cells transplanted into embryos or adult animals; this zebrafish xenograft mo...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Abstract Healthy hematopoietic stem cells (HSCs) are capable to self-renew and reconstitute the complete hematopoietic system. Upon aging, there is an increased incidence of blood-related diseases. Age-related phenotypes have been widely studied by bone marrow transplantation experiments, where reconstitution of the transplanted cells is a direct measure of HSC activity. In this protocol we describe a competitive bone marrow transplantation assay to functionally test young and old HSCs. PMID: 31197778 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
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